Table 2. Three Thiol-Site Prosthetic Groups Compared in Terms of Radiolabeling Efficiency and Tumor Uptake.
| tracers | mode | method | time (min) | yielda | SA (GBq/μmol) | tumor uptake (%ID/g)b |
|---|---|---|---|---|---|---|
| [18F]FBEM | automated | two-pot three-step | 95 | 17 ± 7% | 91–176c | 30.27 ± 5.44% |
| [18F]FPenM | manual | two-pot three-step | 110 | 14 ± 3% | 20–49c | 33.21 ± 4.79% |
| [18F]FNEM | manual | one-pot two-step | 75 | 26 ± 5% | 19–88c | 23.06 ± 3.87% |
a
Decay uncorrected yield.
b
Tumor uptake is based on biodistribution of corresponding [Cys40]-exendin-4 conjugates.
c
Specific activity of the prosthetic agents after purification.