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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Cell Mol Bioeng. 2014 Aug 8;7(4):510–520. doi: 10.1007/s12195-014-0351-x

Figure 11.

Figure 11

Proposed pathway for the mechanism of shear stress-induced NO. Flow causes the release of ATP in nM-μM levels, which activate purnergic receptors causing the release of IP3 and DAG. IP3 then causes the ER to deplete intracellular calcium stores. Depletion of ER calcium stores leads to the activation of store-operated channels (SOCs) (known as capacitative calcium entry (CCE)), which is PKC-dependent. CCE then activates calcium-dependent calmodulin (Ca+2-CaM), which leads to phosphorylation of eNOS and production of NO.