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. Author manuscript; available in PMC: 2015 May 6.
Published in final edited form as: Nature. 2014 Sep 7;515(7525):80–84. doi: 10.1038/nature13686

Fig. 3. Architecture of mammalian complex I showing the densities of the supernumerary subunits enclosing the core domain.

Fig. 3

The models for the core subunits are in light colours (as labelled) in surface representation, and density attributed to the supernumerary subunits, forming a cage around the core subunits, is in dark red. The supernumerary subunits are concentrated on each side of the membrane domain, and around the lower section of the hydrophilic domain. The NADH binding site in the 51 kDa subunit is indicated, with the predicted positions for the flavin isoalloxazine (orange spheres) and three conserved phenylalanines at the entry to the site (yellow); the vicinity of this site is devoid of supernumerary subunit density.