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Discriminative stimulus effects (top) and rate-decreasing effects (bottom) of epibatidine (left) and RTI-7527-102 (right), alone and in combination with mecamylamine. Abscissae: mecamylamine (Mec) alone (3.2 mg/kg) or dose in milligram per kilogram body weight. Ordinates: percentage of nicotine-appropriate responses (top) and response rate expressed as a percentage of the control rate of responding (bottom).
