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Hypothermic effects of epibatidine, RTI-7527-36, RTI-7527-76 and RTI-7527-102 alone and in combination with mecamylamine (left) or DHβE (right). Abscissae: dose of epibatidine, RTI-7527-36, RTI-7527-76 or RTI-7527-102 in milligram per kilogram body weight. Ordinates: the area calculated from the hypothermia time course in Figure 4 and expressed as a percentage of the maximum effect for each respective drug.
