Table 1.
ED50 values for discriminative stimulus, rate-decreasing effects, and ED34°C values for hypothermia and corresponding 95% confidence limits. Potency ratios are calculated with epibatidine as a reference, e.g., ED34°C values were divided by the ED34°C values for epibatidine.
| % Nicotine responding | Decreases in response rate | Hypothermia | ||||
|---|---|---|---|---|---|---|
| Drug | ED50 values in mg/kg (95% confidence limits) | Potency ratio (95% confidence limits) | ED50 values in mg/kg (95% confidence limits) | Potency ratio (95% confidence limits) | ED34°C values in mg/kg (95% confidence limits) | Potency ratio (95% confidence limits) |
| Epibatidine | 0.002 (0.001-0.003) | 0.004 (0.002-0.008) | 0.005 (0.004-0.006) | |||
| RTI-7527-36 | 0.023 (0.008-0.062) | 13.0 (3.4-59.2) | 0.11 (0.05-0.22) | 26.4 (14.9-54.6) | 0.07 (0.06-0.09) | 14.3 (11.5-17.8) |
| Nicotine | 0.44 (0.26-0.74) | 248 (108-606) | 0.91 (0.61-1.35) | 217 (116-378) | 1.3 (1.1-1.6) | 347 (263-474) |
| RTI-7527-102 | n/a | n/a | 1.50 (1.01-2.24) | 359 (160-642) | 3.0 (2.6-3.5) | 608 (507-739) |
| RTI-7527-76 | 2.29 (0.80-6.51) | 1290.9 (429.0-7312.7) | 2.52 (1.62-3.92) | 601 (251-1106) | 4.2 (3.5-5.0) | 846 (674-1090) |
| Cytisine | n/a | n/a | 5.62 (3.36-9.38) | 1341 (739-2435) | 4.2 (3.8-4.6) | 850 (709-1040) |
| Varenicline | 2.53 (0.98-6.51) | 1427 (413-7727) | 2.75 (1.55-4.88) | 657 (338-2435) | 4.6 (4.1-5.2) | 994 (775-1160) |