Table 1.
HIV infection in current humanized mouse models
| Research areas | Models | References | |
|---|---|---|---|
| HIV-1 evolution | DKO-hu HSC | Ince et al.,58 2010 | |
| NOG-hu HSC | Sato et al.,59 2010 | ||
| Immune response | NOG-hu HSC | Nie et al.,57 2009 | |
| NOG-hu HSC | Sato et al.,60 2010 | ||
| NSG-BLT | Brainard et al.,52 2009 | ||
| NOD/SCID-BLT | Brainard et al.,52 2009 | ||
| Latency | DKO-HSC | Choudhary et al.,61 2012 | |
| NSG-BLT | Denton et al.,62 2012 | ||
| Marsden et al.,63 2012 | |||
| Mucosal transmission and prevention | DKO-hu HSC | Berges et al.,64 2008 | |
| Hofer et al.,65 2008 | |||
| Neff et al.,66 2010 | |||
| Rag1−/− γC−/−-hu HSC | Akkina et al.,67 2011 | ||
| NSG-BLT | Denton et al.,68 2011 | ||
| Stoddart et al.,24 2011 | |||
| Wheeler et al.,69 2011 | |||
| NOD/SCID-BLT | Sun et al.,56 2007 | ||
| Denton et al.,70 2008 | |||
| Denton et al.,71 2010 | |||
| Denton et al.,68 2011 | |||
| Stoddart et al.,24 2011 | |||
| Immune activation and pathogenesis | Tregs | DKO-hu HSC | Jiang et al.,54 2008 |
| GALT and mucosal microbes | DKO-hu HSC | Hofer et al.,72 2010 | |
| pDCs | DKO-hu HSC | Zhang et al.,73 2011 | |
| Interferon-α | NSG-BLT | Long et al.,74 2012 | |
| Interferon-α | SCID-hu Thy/Liv | Stoddart et al.,75 2010 | |
| Neuropathology | NSG-hu HSC | Dash et al.,76 2011 | |
| Gong et al.,77 2011 | |||
| Gorantla et al.,78 2010 | |||
| Antiviral drug | siRNA | DKO-hu HSC | Neff et al.,79 2011 |
| Zhou et al.,80 2011 | |||
| Ter Brake et al.,81 2009 | |||
| NSG-hu HSC | Kumar et al.,82 2008 | ||
| Kim et al.,83 2010 | |||
| NSG-BLT | Wheeler et al.,69 2011 | ||
| Small molecules | DKO-hu HSC | Choudhary et al.,84 2009 | |
| Sango et al.,85 2010 | |||
| SCID-hu Thy/Liv | Stoddart et al.,46 2007 | ||
| Stoddart et al.,47 2007 | |||
| Peptides | DKO-hu HSC | van Duyne et al.,86 2008 | |
| SCID-hu Thy/Liv | Stoddart et al.,45 2012 | ||
| Gene Therapy | shRNA | NSG-BLT | Shimizu et al.,87 2010 |
| HIV-1 neutralizing antibody | NSG-hu HSC | Joseph et al.,88 2010 |
Abbreviations: BLT, human thymus and liver tissues and HSC; DKO, rag2−/− Il2rg tm1Sug/Jic; hu HSC, human CD34+ hematopoietic stem/progenitor cells; hu Thy/Liv, human thymus and liver tissues; NOG, NOD. Cg-Prkdc scid Il2rg tm1Sug/Jic; NSG, NOD/LtSZ-scid Il2rgnull; pDCs, plasmacytoid dendritic cells; Tregs, regulatory T cells; shRNA, small hairpin RNA; siRNA, small interfering RNA.