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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Neuroscience. 2014 Sep 4;279:168–186. doi: 10.1016/j.neuroscience.2014.08.041

Figure 2.

Figure 2

Network analysis of gene coexpression after chronic intoxication identifies clustering of distinct module eigengenes and traits at each stage of addiction. From the WGCNA analysis, module eigengenes and traits were clustered using an unsigned correlation matrix so that modules with high absolute value correlations grouped together. Consistent with hierarchical clustering analysis, coexpression modules demonstrate the influence of sex during the early stages of intoxication and withdrawal, while selected phenotype/genotype is most influential during abstinence.