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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Neuroscience. 2014 Sep 4;279:168–186. doi: 10.1016/j.neuroscience.2014.08.041

Figure 5.

Figure 5

Confirmation of sexually dimorphic immune signaling using focused qPCR immune function arrays. Volcano plots of expression differences in WSR male (on the right) and female (on the left) mPFC. The plots identify sequences that are differentially expressed during withdrawal as a consequence of chronic ethanol intoxication. Females exhibit up-regulation of several key inflammatory mediators such as TNF-α, IL-6, CCL11 and CCL5 while males exhibit a profound down-regulation of several chemokines, cytokines and co-stimulatory molecules indicative of a relative immunosuppression.