Table 1.
Hub proteins identified in the zebrafish intracellular PPI network for primary infection
| Rank | Zebrafish protein | Degree | GO functional annotation |
|---|---|---|---|
| 1 | Tfap2a | 10 | Regulation of cell differentiation |
| 2 | Gch2 | 10 | Response to interferon γ |
| 3 | Hsp90a.1 | 10 | Fc-γ receptor signaling |
| 4 | Acvr1b | 9 | TGF-β receptor activity |
| 5 | Btg2 | 9 | Negative regulation of cell proliferation |
| 6 | Cct5 | 9 | Response to virus |
| 7 | Clock | 9 | Circadian rhythm |
| 8 | Fkbp5 | 9 | Heat shock protein binding |
| 9 | Fos | 9 | Innate immune response |
| 10 | Ncstn | 9 | T cell proliferation |