Table 2.
Hub proteins identified in the zebrafish intracellular PPI network for secondary infection
| Rank | Zebrafish protein | Degree | GO functional annotation |
|---|---|---|---|
| 1 | Psmd1 | 16 | Antigen processing and presentation of exogenous peptide antigen via MHC class I |
| 2 | Fos | 12 | Innate immune response |
| 3 | Psmd13 | 11 | Antigen processing and presentation of exogenous peptide antigen via MHC class I |
| 4 | Ndrg1 | 10 | Mast cell activation |
| 5 | Casp2 | 10 | Regulation of apoptosis |
| 6 | Gch2 | 10 | Response to interferon-γ |
| 7 | Ncstn | 9 | T cell proliferation |
| 8 | Acvr1b | 9 | TGF-β receptor activity |
| 9 | Uba5 | 9 | Protein ubiquitination |
| 10 | Usp14 | 8 | Regulation of proteasomal protein catabolic process |