Table 1.
OncoCis annotation of the TERT promoter mutations chr5:1,295,228 G > A and 1,295,250 G > A
| Motifs | Fantom5 | RegulomeDB | Funseq | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chromosome | Position | Gene | Distance to TSS | DHS | H3K4me1 | H3K4me3 | H3K27ac | Conservation mutated base | Created | Removed | Promoter | Enhancer | Category | Sensitive? |
| Chr5 | 1,295,228 | TERT | -66 | 1 | 0 | 1 | 0 | 0.008 | ELK1;ELF1;FLI1;ELK4;GABPA | TFAP2A | 1 | 0 | 2b | No |
| Chr5 | 1,295,250 | TERT | -88 | 1 | 0 | 1 | 0 | 0 | ELK1;ELF1;FLI1;ELK4;GABPA | - | 1 | 0 | 4 | No |
The category and whether the mutation falls within a ‘sensitive’ region as defined by RegulomeDB and Funseq, respectively, are also shown.