Table 2.
Relationship between rs9939609 polymorphism
| Outcomes | All patients | TT | AT | AA | P -value (a) | aAMR (95%CI) | P -value (b) |
|---|---|---|---|---|---|---|---|
| Continuous variables | |||||||
| BMI (kg/m2) | 23.29 ± 0.25 | 22.69 ± 0.35 | 22.91 ± 0.32 | 24.29 ± 0.58 | 0.016 | 1.08 (1.03; 1.14) | 0.002 |
| HOMA-IR | 3.24 ± 0.19 | 2.97 ± 0.29 | 2.75 ± 0.26 | 4.19 ± 0.47 | 0.003 | 1.32 (1.03; 1.69) | 0.027 |
| All patients | TT | AT | AA | P -value (a) | aOR (95%CI) | P -value (b) | |
| Categorical variables | |||||||
| Overweight (BMI ≥27.5 kg/m2) | 8.5% (22/260) | 4% (4/100) | 8.9% (11/123) | 19.4% (7/36) | 0.011 | 3.46 (1.17; 10.21) | 0.024 |
| HOMA-IR ≥2.5 | 41.4% (108/261) | 38.6% (39/101) | 39% (48/123) | 56.8% (21/37) | 0.040 | 2.09 (1.02; 4.32) | 0.045 |
| Significant fibrosis (F ≥ 2) | 48.6% (102/210) | 48.8% (41/84) | 43.3% (42/97) | 65.5% (19/29) | 0.049 | 2.34 (1.02; 5.36) | 0.045 |
| Steatosis (>10% fatty hepatocytes) | 56.9% (115/202) | 51.9% (41/79) | 57% (53/93) | 70% (21/30) | 0.117 | 3.65 (1.29;10.36) | 0.015 |
a P-values were calculated by Chi-square tests for categorical variables and generalized linear models (GLM) with normal distribution (log-link) for continuous variables; b P-values were calculated by GLM adjusted by the most important clinical and epidemiological characteristics (see Statistical analysis section). Metabolic disturbances and liver disease in HIV/HCV-coinfected patients. Categorical variables are expressed in percentage (absolute count) and continuous variables are expressed in estimated marginal mean ± standard error of the mean. Statistically significant differences are shown in bold. 95%CI, 95% confidence interval; aAMR, adjusted arithmetic mean ratio; aOR, adjusted odds ratio; BMI, body mass index; HCV, hepatitis C virus; HIV, human immunodeficiency virus; HOMA-IR, homeostatic model assessment-insulin resistance.