Table 1.

Summary of model simulated DRV C_trough concentrations in the absence and presence of RIF and following dose adjustment in combination with RIF. The changes in simulated DRV C_trough are presented as GMR (90% CI)

Regimen	Geometric mean (90% CI)	GMR (90% CI)
800/100 mg qd -RIF (reference)	1.642 (1582–1.702)	–
800/100 mg qd +RIF	0.486 (0.461–0.511)	0.296 (0.293–0.299)
1200/200 mg qd +RIF	0.883 (0.839–0.927)	0.538 (0.533–0.542)
800/100 mg bid +RIF	1.311 (1.262–1.359)	0.798 (0.761–0.837)
1200/150 mg bid +RIF	2.270 (2.191–2.349)	1.383 (1.319–1.449)