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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: ChemMedChem. 2014 May 14;9(7):1602–1614. doi: 10.1002/cmdc.201300546

Table 1.

Inhibitory potencies (IC50) on human NAAA of compounds 11a–h[a]

Compounds Structure h–NAAA IC50 (μM) ± S.E.M
11a graphic file with name nihms597376t1.jpg Not active[b]
11b graphic file with name nihms597376t2.jpg 73.36 ± 10.68
11c graphic file with name nihms597376t3.jpg 27.16 ± 1.89
11d graphic file with name nihms597376t4.jpg 12.06 ± 2.18
11e graphic file with name nihms597376t5.jpg 0.60 ± 0.17
11f graphic file with name nihms597376t6.jpg 27.02 ± 6.15
11g graphic file with name nihms597376t7.jpg 1.91 ± 0.28
11h graphic file with name nihms597376t8.jpg 0.34 ± 0.03
[a]

IC50 values are reported as mean values of three or more determinations.

[b]

Not active: < 10% inhibition @ 50 μM.