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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: ChemMedChem. 2014 May 14;9(7):1602–1614. doi: 10.1002/cmdc.201300546

Table 3.

Inhibitory potencies (IC50) on human NAAA of analogues of compound 11h[a]

Compounds Structure h–NAAA IC50 (μM) ± S.E.M
12h graphic file with name nihms597376t9.jpg 74.52 ± 9.08
21h graphic file with name nihms597376t10.jpg Not active[b]
22h graphic file with name nihms597376t11.jpg Not active[b]
23h graphic file with name nihms597376t12.jpg Not active[b]
24h graphic file with name nihms597376t13.jpg Not active[b]
27h graphic file with name nihms597376t14.jpg Not active[b]
28h graphic file with name nihms597376t15.jpg Not active[b]
32 graphic file with name nihms597376t16.jpg Not active[b]
[a]

IC50 values are reported as mean values of three or more determinations.

[b]

Not active: < 10% inhibition @ 50 μM.