Table 4.

Inhibitory potencies (IC₅₀) on human NAAA of compounds 11i–q, 33 and 34^[a]

Compounds	Structure	h–NAAA IC50 (μM) ± S.E.M
11i		3.09 ± 0.50
11j		3.90 ± 0.86
11k		13.85 ± 3.41
11l		Not active[b]
11m		0.22 ± 0.03
11n		0.76 ± 0.26
11o		0.24 ± 0.03
11p		0.10 ± 0.02
11q		0.28 ± 0.07
33		5.76 ± 0.90
34		0.24 ± 0.02

^[a] IC₅₀ values are reported as mean values of three or more determinations.

^[b] Not active: < 10% inhibition @ 50 μM.