Table 5.

Inhibitory potencies (IC₅₀) on human NAAA^[a], human AC^[a] and % inhibitory activity (% inhib) on human FAAH of compounds 11h, 12h and 11p

Compounds	h–NAAA IC50 (μM) ± SD	h–AC IC50 (μM) ± SD	h–FAAH (% Inhib)[b]
11h	0.13 ± 0.03	2.53 ± 0.06	n.a.
12h	45.54 ± 19.94	27.81 ± 5.38	n.a.
11p	0.056 ± 0.010	0.33 ± 0.10	n.a.

^[a] IC₅₀ values are measured by LC/MS method and reported as mean values of three or more determinations.

^[b] Not active: < 10% inhibition @ 100 μM