Table 6.
Plasma pharmacokinetic parameters of compound 11h after a single intravenous (3.0 mg kg−1) or oral administration (10 mg kg−1) in rats
| Parameters | 3.0 mg kg−1 (IV)[a] | 10mg kg−1 (PO)[a] |
|---|---|---|
| Cmax (ng mL−1) | 397 | 570 |
| Tmax (h) | 0.08 | 0.25 |
| AUC (ng h mL−1) | 111 | 247 |
| Cl (mL min−1 kg−1) | 702 | |
| F (%) | 67 |
Cmax = Maximum observed concentration; AUC = Cumulative area under curve for experimental time points (0–24 h); Cl = Systemic clearance based on observed data points (0–24 h); F = Bioavailability.
[a]
Compound was dosed in 10% PEG400/10% Tween 80/80% Saline solution; three animals per dose were treated.