Table 3. Multiple Comparisons (Tukey’s HSD post hoc tests) of the 12 N-Glycopetides in Final Validation Cohort^a.

variables		mean difference (vs group CTRL (age 50+))
protein	peptide sequence	CTRL (age ≤ 50)	PD (UPDRS < 15)	PD (UPDRS 15∼30)	PD (UPDRS > 30)	PD-All (age 50+)	AD
CHL1	ISGVN∧LTQK	–6.778b	1.367	3.789	0.503	3.048	–1.059
CHL1	IIPSN∧NSGTFR	–4.399c	1.389	2.445	1.629	2.593	3.564
GOLM1	AVLVNN∧ITTGER	–5.191b	2.835	3.961c	2.393	4.507c	1.906
HSPG2	ALVN∧FTR	–7.967b	–0.102	0.545	0.162	0.336	–0.164
HYOU1	AEPPLN∧ASASDQGEK	–0.962	–0.144	4.076c	2.243	2.787	1.336
ICAM1	AN̂LTVVLLR	–2.847	2.248	2.458	0.785	2.737	1.585
LSAMP	LGVTN̂ASLVLFR	3.13	3.109	1.472	0.21	2.13	0.542
MEGF8	ALLTN∧VSSVALGSR	–0.537	–0.288	1.485	–0.106	0.67	0.228
NCAM1	DGQLLPSSN∧YSNIK	1.431	3.296	3.32	2.737	4.563c	4.39c
PRNP	GEN∧FTETDVK	–1.923	2.403	4.39c	2.298	4.42c	0.642
SEMA4D	AAN∧YTSSLNLPDK	–1.414	3.002	2.61	0.099	1.621	0.721
TNC	N∧TTSYVLR	–4.816b	0.676	0.922	–0.01	0.881	0.443

^aNotes: N^∧: deamidated asparagine residues. Settings in Tukey’s HSD post hoc tests: alpha = 0.05; n = average sample numbers in the two comparison groups. Proteins and peptides in bold are those with statistical alterations unique to PD (vs age-matched controls and AD).

^bSignificance level: p < 0.01.

^cSignificance level: p < 0.05.