. Author manuscript; available in PMC: 2015 Nov 1.

Published in final edited form as: Obesity (Silver Spring). 2014 Aug 6;22(11):2361–2369. doi: 10.1002/oby.20854

Table 3.

Glycemic characteristics of the eight trajectory-groups

Group	IFG (%)	IGT (%)	IGR (%)	T2D ever (%)	T2D ever Odds ratio	Fasting glucose (mg/dL)	2-h glucose (mg/dL)	2-h glucose Odds ratio	Fasting glucose change (mg/dL)	2-h glucose change (mg/dL)	Fasting insulin (mU/L)	2-h insulin (mU/L)	2-h insulin Odds ratio	Fasting insulin change (mU/L)	2-h insulin change (mU/L)
1	4.2^*	5.7	5.7^*	20.2	1.50 (0.72-3.11)^*	87.0 ± 6.7^*	99.5 ± 23.5	1.29 (1.06-1.58)^*	3.9 ± 10.1	20.2 ± 33.6^*	17 (9 - 23)^*	80 (45 - 123)^*	1.09 (1.02-1.15)^*	–7 (–13 - –2)	–19 (–36 - 12)
2	4.3^*	3.1	6.3^*	25.8^#	2.06 (1.08-3.95)^*	87.6 ± 7.2^*	97.8 ± 22.4^*	1.15 (0.97-1.37)	6.1 ± 12.3^*	18.5 ± 35.2^*	15 (10 - 23)^*	71 (37 - 117)^*	1.06 (1.01-1.11)^*	–6 (–11 - 1)^*	–9 (–40 - 47)
3	10.2^*	3.4	11.7^*	29.5^#	2.48 (1.31-4.70)^*	89.8 ± 7.7^*	99.4 ± 20.9^*	1.09 (0.94-1.27)	6.2 ± 12.9^*	20.7 ± 37.3^*	18 (10 - 30)^*	72 (37 - 130)^*	1.04 (1.01-1.08)^*	–2 (–15 - 5)^*	6 (–37 - 65)^*
4	10.5^*	6.2	14.5^*	34.5^#	3.12 (1.62-6.03)^*	90.3 ± 8.1	101.9 ± 23.5	0.95 (0.84-1.07)	9.8 ± 13.2^*	25.1 ± 39.6^*	22 (13 - 30)^*	81 (38 - 135)^*	0.98 (0.94-1.01)	–1 (–13 - 9)^*	10 (–38 - 86)^*
5^¥	26.7	6.9	31.9	14.4	1.00^¥	93.2 ± 10.0	107.7 ± 22.7	1.00^¥	1.0 ± 13.0	1.4 ± 30.1	28 (17 - 39)	96 (65 - 170)	1.00^¥	–15 (–25 - –3)	–38 (–87 - –8)
6	19.5	5.6	24	32.6^#	2.87 (1.38-5.96)^*	91.7 ± 8.3	102.2 ± 25.3	0.86 (0.75-0.99)^*	8.5 ± 12.2^*	22.7 ± 35.0^*	23 (13 - 33)	86 (49 - 134)	0.97 (0.93-1.01)	2 (–13 - 12)^*	7 (–51 - 84)
7	16.3^*	4.9	16.3^*	27.9^#	2.29 (1.02-5.15)^*	92.6 ± 8.3	104.3 ± 22.4	0.83 (0.69-0.99)^*	6.8 ± 11.2	22.9 ± 36.5^*	30 (14 - 43)	114 (51 - 160)	0.99 (0.95-1.04)	–10 (–21 - 3)	–16 (–113 - 66)
8	17.9^*	0	17.9^*	32.3^#	2.82 (1.09-7.33)^*	93.4 ± 6.8	104.3 ± 17.2	0.82 (0.63-1.06)	8.8 ± 13.4^*	19.0 ± 27.6	34 (22 - 57)	122 (102 - 200)	0.99 (0.94-1.06)	–6 (–19 - 13)	–24 (–73 - 11)

Total	11.6	4.5	14.1	27.6	-	90.0 ± 8.1	100.7 ± 22.6	-	6.4 ± 12.6	19.7 ± 36.2	19 (12 - 31)	84 (42 - 135)	-	–5 (–15 - 4)	–5 (–48 - 53)

P <0.05 vs. Group 5 using Dunnet's test

^¥

Reference group.

Glucose and insulin values given are baseline values at the first visit. Changes are defined as difference between follow-up and baseline visits values.

Legend:

IFG - Impaired Fasting Glucose (FPG: 100-125 mg/dL);

IGT - Impaired Glucose Tolerance (2hPG: 140-199 mg/dL).

IGR - Impaired Glucose Regulation (FPG: 100-125 mg/dL and/or 2hPG: 140-199 mg/dL)

T2D - Type 2 Diabetes

Odds Ratio calculations: 2-h glucose: per 10-mg/dL in 2-h glucose; 2-h insulin: per 10-mU/L in 2-h insulin

2-h glucose analyses adjusted for age, weight and sex; 2-h insulin analyses adjusted for age, weight, sex 2-h glucose