Table 2.

Pharmacological characterization of analogs 3.1–3.12 as inhibitors at HEK293 cells stably expressing human EAAT1-3 in the [ ¹ H]-D-aspartate uptake assay (Jensen & Bräuner-Osborne 2004 )

	R 2	EAAT1	EAAT2	EAAT3
(±)- endo-exo -3.1		>300	>300	>300
(±)- endo-exo -3.2		>300	>300	>300
(±)- endo-exo -3.3		>100	>100	>100
(±)- endo-exo -3.4		>100	~100	>300
(±)- endo-exo -3.5		~300	>300	>300
(±)- endo-exo -3.6		>100	~100	>100
(±)- endo-exo -3.7		~300	~300	>300
(±)- endo-exo -3.8		>300	>300	>300
(±)- endo-exo -3.9		>300	>300	>300
(±)- endo-exo -3.10		>300	>300	>300
(±)- endo-exo -3.11		>300	>300	>300
(±)- endo-exo -3n12		>100	~100	>100

All values are given as IC₅₀ in μM with pIC₅₀ ± S.E.M. values in brackets (for the active analogs).