Table 1.
Concentration of mediators in synovial fluid of patients with primary knee and posttraumatic wrist osteoarthritis
| Chondrodestructive | Wrist OA (median ± IqR) | Knee OA (median ± IqR) | P value |
|---|---|---|---|
| IL-1a | 27 (14-51) | 0.91 (0-1.4) | <0.001 |
| IL-1b | ND | ND | |
| IL-7 | ND | ND | |
| IL-8 | 85 (51-162) | 52 (34-71) | 0.0397 |
| IL-17 | 353 (213-570) | 9.6 (3.8-16) | <0.001 |
| CCL5 | 3554 (2170-5535) | 209 (86-395) | <0.001 |
| IFN-g | 146 (83-183) | 5.6 (4.7-10) | <0.001 |
| LIF | 431 (183-661) | 11 (5.9-21) | <0.001 |
| OSM | 40 (17-61) | 0.49 (0-5.0) | <0.001 |
| TNF-a | 1.0 (0-3.6) | ND | 0.0011 |
| VEFG | 131 (82-325) | 216 (126-358) | 0.0989 |
| Chondroprotective | |||
| IL-1RA | 249 (155-390) | 18 (15-25) | <0.001 |
| IL-4 | ND | ND | |
| IL-10 | 259 (217-473) | 39 (35-56) | <0.001 |
| IL-13 | ND | 0 (0-0.73) | 0.009 |
| OPG | 721 (391-1215) | 2137 (802-6575) | 0.0045 |
| Chondromodulatory | |||
| IL-6 | 533 (404-713) | 39 (27-83) | <0.001 |
OA = osteoarthritis; IqR = interquartile range
Concentrations are in 10-3picogram mediator / microgram protein / ml