SNP rs: 1800497 |
TaqA1 allele associates with sever alcoholism |
Blum et al. (1990) |
First study to associate with alcoholism (called reward gene) |
ANKKI -p.Glu713Lys |
DRD2 Taq1A RFLP is a single nucleotide polymorphism (SNP) that causes an amino acid substitution within the 11th ankyrin repeat of ANKK1 |
Neville et al. (2004) |
The ANKKI gene is a reflection of DRD2 A1 allele |
SNP rs: 1800497 |
This SNP has been found to predict future RDS behaviors as high as 74 % |
Blum et al. (1996) |
Using Bayesian analysis |
SNP rs: 1800497 |
Presence of the A1+ genotype (A1/A1, A1/A2) compared to the A− genotype (A2/A2), is associated with reduced density |
Noble et al. (1991) |
This reduction causes hypodopaminergic functioning in the dopamine reward pathway |
SNP rs: 6277 at exon 7 |
T+ allele associates with alcohol dependence |
Hill et al. (2008) |
Associates with drug seeking behavior and other RDS behaviors |
SNP rs: 1800497 |
10 year follow up that carriers of the DRD2 A1 allele have a higher rate of mortality compared to carriers of the A2 allele in alcohol dependent individuals |
Dahlgren et al. (2011) |
Taq IA1allele and a substantially increased relapse rate |
DRD2-haplotypes I-C-G-A2 and I-C-A-A1 |
Confirmed the hypothesis that haplotypes, which are supposed to induce a low DRD2 expression, are associated with alcohol dependence |
Kraschewski et al. (2009) |
High frequency of haplotype was associated with Cloninger Type 2 and family history of alcoholism |
SNP rs: 1800497 |
Genotype analysis showed a significantly higher frequency for the TaqIA polymorphism among the addicts (69.9 %) compared to control subjects (42.6 %; Fisher’s exact χ(2), P < 0.05) |
Teh et al. (2012) |
The addicts had higher scores for novelty seeking (NS) and harm avoidance (HA) personality traits |