Table 2.

Genetic burden and disease phenotype in Crohn’s disease

Phenotype	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P(linear trend)
Age at diagnosis	0 (Reference)	−3.2 (−5.9 to −0.4)	−3.6 (−6.4 to −0.8)	−4.9 (−7.7 to −2.1)	0.008
Ileal disease	1 (Reference)	1.5 (0.9 - 2.4)	1.9 (1.2 – 3.1)	2.5 (1.5 – 4.1)	< 0.0001
Perianal disease	1 (Reference)	1.5 (0.9 – 2.4)	1.4 (0.9 – 2.2)	1.2 (0.7 – 2.0)	0.66
Complicated CD	1 (Reference)	0.9 (0.6 – 1.4)	0.9 (0.6 – 1.4)	1.3 (0.8 – 2.0)	0.09
Bowel resection	1 (Reference)	1.4 (0.9 – 2.1)	1.2 (0.8 – 1.8)	1.5 (1.0 – 2.3)	0.05
IMM use	1 (Reference)	2.3 (1.4 – 3.7)	1.4 (0.9 – 2.2)	1.9 (1.2 – 3.1)	0.07
Anti-TNF use	1 (Reference)	1.9 (1.2 – 2.9)	1.4 (0.9 – 2.2)	1.4 (0.9 – 2.1)	0.38
Family history	1 (Reference)	1.3 (0.8 – 2.1)	1.1 (0.7 – 1.7)	1.2 (0.7 – 1.9)	0.49