Table 3.

Genetic burden and disease phenotype in Ulcerative colitis

Phenotype	Quartile 1	Quartile 2	Quartile 3	Quartile 4	P(linear trend)
Age at diagnosis	0 (Reference)	0.2 (−3.4 to 3.8)	−1.6 (−5.2 to 2.0)	−0.8 (−4.5 to 2.7)	0.39
Pancolitis	1 (Reference)	1.4 (0.8 – 2.5)	1.3 (0.7 – 2.2)	1.3 (0.8 – 2.3)	0.76
Colectomy	1 (Reference)	3.0 (1.1 – 7.8)	1.4 (0.5 – 4.1)	1.2 (0.4 – 3.6)	0.92
IMM use	1 (Reference)	0.8 (0.5 – 1.4)	1 (0.6 – 1.8)	0.8 (0.5 – 1.4)	0.70
Anti-TNF use	1 (Reference)	0.7 (0.4 – 1.4)	0.9 (0.5 – 1.6)	0.9 (0.5 – 1.6)	0.63
Family history	1 (Reference)	1.5 (0.7 – 3.0)	1.3 (0.6 – 2.7)	1.9 (1.0 – 3.9)	0.03