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. Author manuscript; available in PMC: 2014 Nov 9.
Published in final edited form as: J Immunol. 2008 Oct 1;181(7):4989–5000. doi: 10.4049/jimmunol.181.7.4989

FIGURE 4.

FIGURE 4

Cathelicidin administration protects C57BL/6 mice from s.c. spore challenge. A–C, Survival of mice inoculated s.c. with 5 LD50 (5 × 105) of spores in 200 µl of PBS (n = 12 mice) or 50 µM solutions of PG-1 (A), CRAMP (B), or LL-37 (C) simultaneously (0 h) or 4 or 24 h after infection (n = 10 mice per group). D–F, Survival of mice inoculated s.c. with 5 LD50 (5 × 105) of spores in 200 µl of PBS (n = 20 mice) or 50 µM or 10 µM solutions of PG-1 (D), CRAMP (E), or LL-37 (F; = 5 10 mice per group). In both experiments, mice were monitored for 10 days, and log rank tests were utilized to determine whether differences in survival were statistically significant.