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. Author manuscript; available in PMC: 2014 Nov 9.
Published in final edited form as: J Immunol. 2008 Oct 1;181(7):4989–5000. doi: 10.4049/jimmunol.181.7.4989

FIGURE 9.

FIGURE 9

Gr-1 depletion abrogates CRAMP- and LL-37-, but not PG-1-, induced protection of C57BL/6 mice challenged s.c. with spores. Survival curves of mice injected i.p. with 50 µg of an anti-GR-1 mAb to deplete neutrophils or an isotype-matched control Ab. The following day, 5 LD50 (5 × 105) of spores were coadministered s.c. in 200 µl of PBS (A) or 50 µM solutions of PG-1 (B), CRAMP (C), or LL-37 (D), and survival was monitored for 10 days. Log rank tests were conducted to determine whether differences in survival were statistically relevant. n = 10 mice per group.