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. 2014 Nov 4;20:1527–1544.

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Copyright © 2014 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Full-field (ganzfeld) ERG testing of Pde6b^rd10/rd10 mice treated with systemic valproic acid (VPA; P17–P28, later treatment). Bilateral full-field electroretinography (ERG) testing was completed on dark-adapted mice at age P27. A: Graph of the dark-adapted B-wave amplitudes from VPA-treated (n = 3) and PBS-treated (n = 2) littermates (mean±standard deviation) at age P27. Amplitudes for each individual were calculated as an average of both eyes. VPA-treated mice had reduced amplitudes relative to PBS-treated controls over the range shown. B: Examples of bilateral full-field ERG traces from VPA-treated and PBS-treated littermates for the dome flash intensity of 4 cd-sec/m². ERG responses were similar between contralateral eyes.