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. 2014 Nov 4;20:1527–1544.

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Copyright © 2014 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Daily systemic valproic acid (VPA; P17–P28, later treatment) increased the rate of photoreceptor loss in Pde6b^rd10/rd10 mice. Retina sections are shown from two different treated and two different control littermates at age P28. White arrows indicate the outer nuclear layer and regions shown at higher magnification (inserts). Daily injections (IP) of 350 mg/kg VPA from age P17 to P28. A: Central retina; B: middle retina; C: peripheral retina (sections are paraffin, hematoxylin and eosin stained).