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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Pharm Res. 2014 May 30;31(12):3379–3389. doi: 10.1007/s11095-014-1427-y

Figure 2.

Figure 2

Release curves for a) cefazolin, b) ciprofloxacin, c) clindamycin, d) colistin, e) doxycycline, and f) vancomycin loaded PLGA microparticles at 10 wt% and 20 wt%. Significant differences between release rates during different phase are indicated by letters. For ciprofloxacin loaded MPs, there is a significant different between 10 wt% and 20 wt% loaded MPs during Phase 1 (p<0.05). For colistin loaded PLGA MPs, Phase 2 and Phase 3 are significantly different between 10 wt% and 20 wt% loaded MPs (p<0.05). Ciprofloxacin and doxycycline 10 wt% loaded MPs demonstrate increased release of antibiotic during Phase 3 compared to 20 wt% loaded MPs, and vancomycin loaded MPs demonstrate increased release from 20 wt% MPs compared to 10 wt% MPs in phase 4 (p<0.05). Cumulative percent release is the same between 10 wt% and 20 wt% for any antibiotic (p>0.05).