Table I.
Charge, pKa, molecular weight, HPLC retention time, logP, and logS of loaded antibiotics.
| Antibiotic | Antibiotic Class | Charge | pKa | Molecular Weight (g/mol) | Retention time (min) | logP | logS |
|---|---|---|---|---|---|---|---|
| Cefazolin sodium | Cephalosporin | −1 | 2.3 | 476.5 | 14.9 | −0.58 | −3.0 |
| Ciprofloxacin hydrochloride | Fluoroquinolone | +1 | 6.1, 8.7 | 331.3 | 15.1 | −0.57 | −2.4 |
| Clindamycin hydrochloride | Lincosamide | +1 | 7.79 | 461.4 | 18.4 | 2.16 | −2.1 |
| Colistin sulfate | Polymyxin | +5 | 10.3 and above | 1155.4 | 14.8/16.3 | −2.4 | −3.7 |
| Doxycycline hyclate | Tetracycline | 1 | 3.4, 7.7, 9.3 | 512.9 | 18.5 | −0.02 | −2.9 |
| Vancomycin hydrochloride | Glycopeptide | +1 | 2.6, 7.7, 8.6, 9.6, 10.5, 11.7 | 1485.7 | 11.9 | −3.1 | −3.8 |