Table V.

MIC of fresh antibiotics and antibiotics released from PLGA microparticles against susceptible strains at early and late time points.

Antibiotic loaded into PLGA MPs	Bacterial Strain	MIC of fresh antibiotic (μg/mL)	MIC of antibiotic from 10 wt% PLGA MPs (μg/mL)		MIC of antibiotic from 20 wt% PLGA MPs (μg/mL)
			Early	Late	Early	Late
Cefazolin	S. aureus	0.25 ± 0.00	0.25 ± 0.00	0.25 ± 0.00	0.25 ± 0.00	0.25 ± 0.00
Ciprofloxacin	P. aeruginosa	0.10 ± 0.04	0.13 ± 0.00	0.13 ± 0.00	0.13 ± 0.00	0.13 ± 0.00
Clindamycin	S. aureus	0.19 ± 0.00	0.19 ± 0.00	0.19 ± 0.00	0.19 ± 0.00	0.19 ± 0.00
Colistin	E. coli	5.33 ± 2.31	8.56 ± 7.04	6.67 ± 2.31	4.00 ± 0.00	5.33 ± 2.31
Doxycyline	S. aureus	0.13 ± 0.00	0.13 ± 0.00	0.13 ± 0.00	0.13 ± 0.00	0.13 ± 0.00
Vancomycin	S. aureus	0.25 ± 0.00	0.29 ±0.19	0.13 ± 0.00	0.33 ± 0.14	0.42 ± 0.14

Data is presented as mean ± standard deviation, n=3 per group