Table 4.
Markers associated with Change in HAI or Fibrosis Stage in Paired Biopsies from Training cohort.
| Type | Biomarker | Williams Statistic | p-value | Marker Direction |
|---|---|---|---|---|
| HAI Change | ALT (IU/L) | 3.5762 | 0.0003 | Increase |
| HAI Change | GGT (IU/L) | 3.4724 | 0.0004 | Increase |
| HAI Change | HA (ng/ ml) | 1.7823 | 0.0470 | Increase |
| HAI Change | ICAM1 | 2.3291 | 0.0124 | Increase |
| HAI Change | IL4 | 1.7597 | 0.0493 | Increase |
| HAI Change | CXCL10 | 2.5376 | 0.0071 | Increase |
| HAI Change | CXCL9 | 2.8528 | 0.0028 | Increase |
| HAI Change | PAI-1 | 1.9754 | 0.0302 | Decrease |
| HAI Change | VCAM1 (pg/ ml) | 2.9859 | 0.0019 | Increase |
| Fibrosis Change | GMCSF (pg/ml) | 1.8325 | 0.0419 | Decrease |
| Fibrosis Change | IL12p70 (pg/ml) | 3.0888 | 0.0013 | Decrease |
| Fibrosis Change | IL2 (pg/ml) | 2.3697 | 0.0111 | Decrease |
| Fibrosis Change | MMP13 (pg/ml) | 2.0962 | 0.0225 | Decrease |
HAI change indicates ± 2 Histologic necroinflammatory activity score;
Fibrosis change indicates ± 1 METAVIR fibrosis stage