Figure 1.

Flow chart of participant selection for the meta-analyses. Selection of samples for the main meta-analysis associating DSPS phenotype with SNPs is diagrammed. At progressive stages, samples were excluded if the DSPS phenotype determination was missing or ambiguous (e.g., a control volunteer who was rated possible DSPS). Because logistic regressions of the mixed-ancestry groups demonstrated excessive genomic inflation, those of non-European ancestry or uncertain ancestry were excluded from the meta-analysis. Samples were also dropped if covariate data were missing or if the genotype call for a particular SNP failed quality control. However, in supplementary analyses, we considered those with non-European ancestry (a mixture of African, Asian, Pacific Island, and Native American ancestry and mixed ancestries) as a group, and we considered all participants regardless of ancestry. DNA selections were similar for the DSPS-case-control phenotype and for the BALM quantitative phenotype.