Table 2.
Sensitivity and specificity for different cut-off levels for CIN 2+ (CIN 2, CIN 3 and invasive cervical cancer; nurses, n=228)
| Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|
| Gynocular | ||||
| 10 vs <10 | 2.8% (0.1% to 14.5%) | 99.5% (97.1% to 100.0%) | 84.3% (78.9% to 88.8%) | 50.0% (1.3% to 98.7%) |
| ≥9 vs <9 | 13.9% (4.7% to 29.5%) | 96.8% (93.2% to 98.8%) | 85.5% (80.1% to 89.9%) | 45.5% (16.7% to 76.6%) |
| ≥8 vs <8 | 30.6% (16.3% to 48.1%) | 90.5% (85.4% to 94.3%) | 87.2% (81.7% to 91.6%) | 37.9% (20.7% to 57.7%) |
| ≥7 vs <7 | 44.4% (27.9% to 61.9%) | 80.4% (74.0% to 85.8%) | 88.4% (82.6% to 92.8%) | 30.2% (18.3% to 44.3%) |
| ≥6 vs <6 | 52.8% (35.5% to 69.6%) | 65.6% (58.4% to 72.4%) | 87.9% (81.4% to 92.8%) | 22.6% (14.2% to 33.0%) |
| ≥5 vs <5 | 66.7% (49.0% to 81.4%) | 43.9% (36.7% to 51.3%) | 87.4% (79.0% to 93.3%) | 18.5% (12.2% to 26.2%) |
| ≥4 vs <4 | 86.1% (70.5% to 95.3%) | 22.2% (16.5% to 28.8%) | 89.4% (76.9% to 96.5%) | 17.4% (12.2% to 23.8%) |
| ≥3 vs <3 | 91.7% (77.5% to 98.2%) | 13.8% (9.2% to 19.5%) | 89.7% (72.6% to 97.8%) | 16.8% (11.9% to 22.8%) |
| ≥2 vs <2 | 94.4% (81.3% to 99.3%) | 6.9% (3.7% to 11.5%) | 86.7% (59.5% to 98.3%) | 16.2% (11.5% to 21.9%) |
| ≥1 vs 0 | 97.2% (85.5% to 99.9%) | 3.2% (1.2% to 6.8%) | 85.7% (42.1% to 99.6%) | 16.1% (11.4% to 21.6%) |
| Colposcope | ||||
| 10 vs <10 | 0.0% (0.0% to 9.7%) | 99.5% (97.1% to 100.0%) | 83.9% (78.5% to 88.5%) | 0.0% (0.0% to 97.5%) |
| ≥9 vs <9 | 11.1% (3.1% to 26.1%) | 96.8% (93.2% to 98.8%) | 85.1% (79.6% to 89.6%) | 40.0% (12.2% to 73.8%) |
| ≥8 vs <8 | 30.6% (16.3% to 48.1%) | 90.5% (85.4% to 94.3%) | 87.2% (81.7% to 91.6%) | 37.9% (20.7% to 57.7%) |
| ≥7 vs <7 | 44.4% (27.9% to 61.9%) | 81.0% (74.6% to 86.3%) | 88.4% (82.7% to 92.8%) | 30.8% (18.7% to 45.1%) |
| ≥6 vs <6 | 52.8% (35.5% to 69.6%) | 66.1% (58.9% to 72.8%) | 88.0% (81.5% to 92.9%) | 22.9% (14.4% to 33.4%) |
| ≥5 vs <5 | 66.7% (49.0% to 81.4%) | 45.0% (37.7% to 52.4%) | 87.6% (79.4% to 93.4%) | 18.8% (12.4% to 26.6%) |
| ≥4 vs <4 | 83.3% (67.2% to 93.6%) | 22.2% (16.5% to 28.8%) | 87.5% (74.8% to 95.3%) | 16.9% (11.7% to 23.3%) |
| ≥3 vs <3 | 91.7% (77.5% to 98.2%) | 14.3% (9.6% to 20.1%) | 90.0% (73.5% to 97.9%) | 16.9% (11.9% to 22.9%) |
| ≥2 vs <2 | 94.4% (81.3% to 99.3%) | 6.9% (3.7% to 11.5%) | 86.7% (59.5% to 98.3%) | 16.2% (11.5% to 21.9%) |
| ≥1 vs 0 | 97.2% (85.5% to 99.9%) | 3.2% (1.2% to 6.8%) | 85.7% (42.1% to 99.6%) | 16.1% (11.4% to 21.6%) |
PPV, positive predictive value; NPV, negative predictive value.