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. 1972 Sep;6(3):326–329. doi: 10.1128/iai.6.3.326-329.1972

Growth of Newcastle Disease Virus and Rubella Virus in Rheumatoid and Nonrheumatoid Synovial Cell Cultures

Spotswood L Spruance 1, Charles B Smith 1, Judith Krall 1, John R Ward 1
PMCID: PMC422535  PMID: 4539128

Abstract

Rheumatoid and nonrheumatoid synovial cell cultures were challenged with Newcastle disease virus and rubella virus in an attempt to confirm reports that rheumatoid synovial cells are relatively resistant to infection with these viruses. Newcastle disease virus caused complete cell destruction by day 7 in both rheumatoid and nonrheumatoid cultures, and peak virus titers were similar. Rubella virus replicated in both rheumatoid and nonrheumatoid synovial cell cultures, and no consistent differences in virus titers were detected. Rubella-infected cell lines were observed for up to 28 days and no virus-specific cytopathic effect was seen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CASTOR C. W., FRIES F. F. Composition and function of human synovial connective tissue cells measured in vitro. J Lab Clin Med. 1961 Mar;57:394–407. [PubMed] [Google Scholar]
  2. Ford D. K. Evidence for an infectious etiology of rheumatoid arthritis. Med Clin North Am. 1968 May;52(3):673–676. [PubMed] [Google Scholar]
  3. Ford D. K., Oh J. O. Use of "synovial" cell cultures in the search for virus in rheumatoid arthritis. Arthritis Rheum. 1965 Dec;8(6):1047–1052. doi: 10.1002/art.1780080604. [DOI] [PubMed] [Google Scholar]
  4. Grayzel A. I., Beck C. Rubella infection of synovial cells and the resistance of cells derived from patients with rheumatoid arthritis. J Exp Med. 1970 Feb;131(2):367–375. doi: 10.1084/jem.131.2.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. PARKMAN P. D., BUESCHER E. L., ARTENSTEIN M. S., MCCOWN J. M., MUNDON F. K., DRUZD A. D. STUDIES OF RUBELLA. I. PROPERTIES OF THE VIRUS. J Immunol. 1964 Oct;93:595–607. [PubMed] [Google Scholar]
  6. Person D. A., Rawls W. E., Sharp J. T. Replication of rubella, Newcastle disease, and vesicular stomatitis viruses in cultured rheumatoid synovial cells. Proc Soc Exp Biol Med. 1971 Nov;138(2):748–752. doi: 10.3181/00379727-138-35981. [DOI] [PubMed] [Google Scholar]
  7. Rawls W. E., Melnick J. L. Rubella virus carrier cultures derived from congenitally infected infants. J Exp Med. 1966 May 1;123(5):795–816. doi: 10.1084/jem.123.5.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Runge L. A., Allison A. C. Growth of rubella virus in cultures of synovial cells from rheumatoid arthritis. Arthritis Rheum. 1972 Jan-Feb;15(1):85–88. doi: 10.1002/art.1780150111. [DOI] [PubMed] [Google Scholar]

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