Table 1.
Characteristics of patients with persistent low level viremia
| Total (n=165) | No switch of cART (n=119) | Switch of cART (n=46) | p | |
|---|---|---|---|---|
| Age±SD (y/o) | 39±11 | 38±11 | 41±10 | 0.096 |
| Male (%) | 158 (95.8%) | 114 (95.8%) | 44 (95.7%) | 0.967 |
| MSM (%) | 122 (73.9%) | 91 (76.5%) | 31 (67.4%) | 0.242 |
| IDU (%) | 25 (15.2%) | 13 (10.9%) | 12 (26.1%) | 0.027 |
| HBV (%) | 19 (11.5%) | 14 (11.8%) | 3 (6.5%) | 0.810 |
| HCV (%) | 28 (17.0%) | 17 (14.3%) | 9 (19.6%) | 0.330 |
| Before cART CD4, median (range), cells/uL | 184 (1–928) | 187 (1–707) | 171 (10–928) | 0.937 |
| Before cART PVL, median, copies/mL, log10 | 5.29 | 5.29 | 5.29 | 0.312 |
| PVL>5 log10 (%) | 98 (59.4%) | 73 (61.3%) | 25 (54.3%) | 0.480 |
| CD4 at LLV, median (range), cells/uL | 422 (63–1092) | 419 (63–1092) | 431 (134–1010) | 0.156 |
| PVL at enrollment, copies/mL | 83 (21–999) | 67 (21–939) | 159 (21–999) | 0.002 |
| PVL of 20–199 (%) | 127 (77.0%) | 100 (84.0%) | 27 (58.7%) | 0.001 |
| PVL of 200–999 (%) | 38 (23.0%) | 19 (16.0%) | 19 (41.3%) | 0.001 |
| Duration of cART exposure, median (range), weeks | 47 (12–391) | 44 (15–321) | 58 (12–391) | 0.062 |
| Years of HIV diagnosed, median, (range), years | 4 (1–14) | 4 (1–14) | 4 (2–13) | 0.356 |
| Ever treatment failure (%) | 42/165 | 26/119 | 16/46 | 0.111 |
| Current cART | ||||
| 2NRTIs+nNRTI | 39 (23.6%) | 39 (32.8%) | 0 (0%) | <0.001 |
| 2NRTIs+PI | 31 (18.8%) | 29 (24.4%) | 2 (4.3%) | 0.003 |
| 2NRTIs+PI/r | 85 (51.5%) | 47 (39.5%) | 38 (82.6%) | <0.001 |
| 2NRTIs+II | 7 (4.2%) | 4 (3.3%) | 3 (6.5%) | 0.967 |
| II+PI/r | 3 (1.8%) | 0 (0%) | 3 (6.5%) | 0.021 |