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. 2014 May 28;40(2):147–159. doi: 10.1111/apt.12807

Figure 2.

Figure 2

Effect of NSAID intake on risk of CRC for carriers of wildtype and variant alleles respectively. (a) rs6983267. (b) IL10 rs3024505, (c) IL1B rs4848306, (d) ABCB1 rs1945642. The P-values in Table 1 indicate whether the slopes of the two lines are different. An interaction effect between NSAID use and a polymorphism may theoretically result in considerable differential impact on the individual risk of CRC. Depending on the disease frequency in the population and the genotype distribution such interaction may also affect the disease frequency in the population. Variant allele frequencies are rs6983267: 0.50, IL10 rs3024505: 0.17, IL1B C-3737T: 0.43, ABCB1 C3435T: 0.59.14,19,46