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. 2014 Apr 14;14(6):1290–1299. doi: 10.1111/ajt.12678

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© 2014 The Authors. American Journal of Transplantation Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Inhibition of immune cell activation induced by shCD154 in vitro. Inhibition of PBMC proliferation stimulated with shCD154 in human, cynomolgus monkey and rabbit samples. The effects of increasing the concentration of ASKP1240 were evaluated. Cell proliferation was measured by incorporation of ³H-thymidine. The percentage of proliferation relative to the ASKP1240 (−) control is plotted as the mean ± SE of three individuals. PBMC, peripheral blood mononuclear cell; shCD154, soluble human CD154.