Table 2.
Average expression of the RHE differentiation markers FLG, TG1, CLD, OCCL and the proliferation marker PCNA (measured as % expression of untreated control) 24 hours after topical treatment with S. epidermidis, P. acnes and S. aureus at different concentrations
| Untreated control | 1×10 7 CFU | 1×10 8 CFU | 1×10 9 CFU | |
|---|---|---|---|---|
|
S. epidermidis
|
|
|
|
|
| FLG |
100 ± 21.1 |
105 ± 50.5 |
113 ± 60 |
99 ± 37.4 |
| TG1 |
100 ± 11 |
95 ± 30.7 |
95 ± 33.5 |
92 ± 25.8 |
| CLD |
100 ± 29.2 |
142 ± 68.3 |
161 ± 105.2* |
123 ± 53.5 |
| OCCL |
100 ± 17.2 |
84 ± 30.9 |
95 ± 35.4 |
113 ± 63.8 |
| PCNA |
100 ± 25.3 |
129 ± 36.2 |
120 ± 39.2 |
135 ± 34* |
|
P. acnes
|
|
|
|
|
| FLG |
100 ± 28 |
110 ± 26.5 |
101 ± 42 |
99 ± 31.4 |
| TG1 |
100 ± 26.9 |
125 ± 74.7 |
84 ± 29.9 |
77 ± 34.6 |
| CLD |
100 ± 36.5 |
90 ± 35.7 |
71 ± 32.1* |
84 ± 31.6 |
| OCCL |
100 ± 33.4 |
112 ± 72.9 |
81 ± 40.5 |
97 ± 42.6 |
| PCNA |
100 ± 18.6 |
102 ± 49.4 |
132 ± 108.2 |
140 ± 93.9 |
|
S. aureus
|
|
1×10
3
CFU |
1×10
5
CFU |
1×10
7
CFU |
| FLG |
100 ± 19.3 |
121 ± 32.6 |
107 ± 20.5 |
141 ± 45.9 |
| TG1 |
100 ± 12 |
179 ± 65.8 |
112 ± 31.7 |
114 ± 34.3 |
| CLD |
100 ± 22.4 |
107 ± 25.3 |
126 ± 30.2 |
141 ± 43.8* |
| OCCL |
100 ± 31.9 |
139 ± 67.7 |
141 ± 43.9 |
143 ± 45.7* |
| PCNA | 100 ± 18 | 104 ± 22.6 | 98 ± 14.3 | 97 ± 48 |
*Single asterisk indicate statistically significant differences (P < 0.05) versus the untreated control.