Table 1.

Measurements of drug levels by HPLC/MS-MS in the cerebellum of symptomatic SCA1 mice at 30–120 min after a single injection of Ro0711401 (10 mg/kg, s.c.)

Time after injection	Cerebellar Ro0711401 levels
	(pg/mg tissue)
30 min	211 ± 20
60 min	135 ± 10
90 min	100 ± 9
120 min	100 ± 40
240 min	80 ± 30
24 hours	N.D.

Values are means ± S.E.M. of 3 animals per time point. N.D. = not detectable.