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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Int Rev Cell Mol Biol. 2014;313:103–144. doi: 10.1016/B978-0-12-800177-6.00004-9

Figure 7. Mutations from the various UCS domain containing proteins mapped onto the Drosophila UNC-45 structure (PDBID 3NOW).

Figure 7

Mutations from S. pombe, C. elegans, zebrafish, Xenopus, mouse and human were mapped onto the Drosophila UNC-45 crystal structure using the protein alignment in Figure 6. A majority of the mutations is located in the UCS domain at the bottom of the figure, which underscores the importance of this domain to UNC-45 function. Residue numbers correspond to those of the mutant organisms. Protein structure modeled in PyMOL (PyMOL Molecular Graphics System, Version 1.6.0.0 Schrödinger LLC).