Table 2.
Meta-analysis results for association between oipA on/off and presence/absence status and PUD and GC
| Variable | No. of studies | No. of cases/controls | OR (95% CI) | P value | I 2 | P het a | P B-D test b |
|---|---|---|---|---|---|---|---|
| For oipA on/off studies | |||||||
| PUD vs. gastritis/FD | |||||||
| All |
10 |
439/583 |
3.97 (2.89,5.45) |
<0.001 |
22.30% |
0.238 |
|
| Region |
|
|
|
|
|
|
0.681 |
| Europe |
7 |
250/285 |
3.75 (2.54,5.53) |
<0.001 |
57.20% |
0.029 |
|
| Asia |
2 |
28/138 |
2.42 (0.61,9.55) |
0.208 |
32.90% |
0.222 |
|
| America |
4 |
161/160 |
4.77 (2.65,8.56) |
<0.001 |
0.00% |
0.902 |
|
| Detection technique |
|
|
|
|
|
|
0.376 |
| PCR based-sequencing |
11 |
359/503 |
3.83 (2.71,5.40) |
<0.001 |
41.10% |
0.075 |
|
| Immunoblot |
2 |
80/80 |
4.42 (1.98,9.83) |
<0.001 |
0.00% |
0.492 |
|
| Age |
|
|
|
|
|
|
0.014 |
| Adult |
11 |
351/470 |
3.26 (2.26,4.69) |
<0.001 |
16.90% |
0.282 |
|
| Children |
2 |
88/113 |
7.03 (3.71,13.34) |
<0.001 |
0.00% |
0.319 |
|
| GU vs. gastritis/FD |
2 |
33/115 |
2.85 (0.94,8.69) |
0.065 |
0.00% |
0.368 |
|
| DU vs. gastritis/FD |
6 |
205/241 |
3.83 2.32,6.34) |
<0.001 |
0.00% |
0.628 |
|
| GC vs. gastritis/FD | |||||||
| All |
5 |
144/287 |
2.43 (1.45,4.07) |
0.001 |
16.80% |
0.308 |
|
| Region |
|
|
|
|
|
|
0.697 |
| Europe |
1 |
9/29 |
4.89 (0.54,44.57) |
0.159 |
/ |
/ |
|
| Asia |
2 |
24/138 |
1.08 (0.29,3.99) |
0.909 |
0.00% |
0.796 |
|
| America |
3 |
111/120 |
2.47 (1.36,4.51) |
0.003 |
51.30% |
0.128 |
|
| Detection technique |
|
|
|
|
|
|
0.034 |
| PCR based-sequencing |
5 |
104/247 |
1.75 (0.96,3.18) |
0.066 |
0.00% |
0.634 |
|
| Immunoblot |
1 |
40/40 |
6.00 (1.79,20.15) |
0.004 |
/ |
/ |
|
| For oipA presence/absence studies | |||||||
| PUD vs. gastritis/FD | |||||||
| All |
7 |
267/486 |
1.93 (0.60,6.25) |
0.278 |
85.70% |
<0.001 |
|
| Region |
|
|
|
|
|
|
<0.001 |
| Asia |
8 |
189/291 |
2.64 (0.85,8.20) |
0.092 |
76.40% |
<0.001 |
|
| Africa |
1 |
78/195 |
0.20 (0.08,0.49) |
<0.001 |
/ |
/ |
|
| GU vs. gastritis/FD |
3 |
93/139 |
3.55 (0.71,17.77) |
0.123 |
76.00% |
0.016 |
|
| DU vs. gastritis/FD |
2 |
60/91 |
3.15 (0.28,35.66) |
0.354 |
87.10% |
0.005 |
|
| GC vs. gastritis/FD | 4 | 101/215 | 2.09 (0.51,8.66) | 0.308 | 79.10% | 0.002 | |
The statistically significant results were highlighted in bold.
a, P value for heterogeneity test; b, P value for Breslow-Day test.
Abbreviations: FD functional dyspepsia, PUD peptic ulcer disease, GU gastric ulcer, DU duodenal ulcer, GC gastric cancer.