Table 1.

Cell-Type- and Phenotype-Specific DHS Enrichment

Tissue Type	Cell Type	Autoimmune		Nonautoimmune	Published
		Genotyped	Imputed	Genotyped
Blood	Primary T helper 1 cells	5.8 (4.2 × 10−6)	10.2 (1.3 × 10−12)	2.1 (3.5 × 10−1)	Maurano et al.3 (CD)
	leukemia cells	3.5 (6.7 × 10−6)	4.7 (5.3 × 10−10)	1.0 (9.8 × 10−1)	–
	lymphoblastoid cells	3.3 (1.1 × 10−5)	4.9 (5.4 × 10−11)	1.0 (9.4 × 10−1)	Maurano et al.3 (MS)
	CD8+ primary cells	3.0 (3.0 × 10−4)	5.4 (1.8 × 10−10)	1.0 (9.6 × 10−1)	Trynka et al.6 (RA)
Fetal kidney	fetal right renal pelvic cells	5.4 (1.4 × 10−4)	8.2 (5.7 × 10−8)	1.5 (7.4 × 10−1)	–
Bone marrow	CD14+ monocytes	4.1 (1.6 × 10−4)	5.7 (2.2 × 10−7)	1.3 (7.6 × 10−1)	Maurano et al.3 (MS)
Fetal thymus	Fetal thymus cells	2.6 (4.0 × 10−4)	4.5 (3.2 × 10−9)	0.8 (6.6 × 10−1)	–

Fold enrichment of $h_g^2$ reported for cell-type-specific DHSs observed as significant in genotype data (after adjustment for 83 cell types tested). We measured enrichment in comparison to $h_g^2$ at DHSs to account for the background DHS enrichment. Results are shown separately from meta-analyses of six autoimmune traits and five nonautoimmune traits. Instances where enrichment was also observed in Trynka et al.⁶ or Maurano et al.³ are indicated.