Table 5.
Results of Cox multivariate analysis
|
Variables |
Total population |
ER-positive patients |
ER-negative patients |
PR-positive patients |
PR-negative patients |
ERBB2-positive patients |
ERBB2-negative patients |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) a | P -value b | HR (95% CI) a | P -value b | HR (95% CI) a | P -value b | HR (95% CI) a | P -value b | HR (95% CI) a | P -value b | HR (95% CI) a | P -value b | HR (95% CI) a | P -value b | |
|
SBR |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| I |
1 |
0.041 |
1 |
0.018 |
|
NS |
1 |
0.00068 |
|
NS |
|
NS |
1 |
0.0034 |
| II |
1.27 (1.01-1.61) |
1.42 (1.06-1.90) |
|
1.87 (1.30-2.68) |
|
|
1.49 (1.14-1.95) |
|||||||
| III |
1.62 (1.02-2.59) |
2.02 (1.13-3.61) |
|
3.49 (1.70-7.17) |
|
|
2.23 (1.31-3.82) |
|||||||
|
pN |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 0 |
1 |
0.00021 |
1 |
0.0024 |
1 |
0.02 |
1 |
0.0097 |
1 |
0.0055 |
1 |
0.0000076 |
|
NS |
| 1-3 |
1.54 (1.22-1.93) |
1.53 (1.16-2.01) |
1.61 (1.08-2.40) |
1.57 (1.12-2.22) |
1.53 (1.13-2.07) |
2.91 (1.82-4.64) |
|
|||||||
| >3 |
2.36 (1.50-3.72) |
2.34 (1.35-4.04) |
2.58 (1.16-5.74) |
2.47 (1.24-4.91) |
2.34 (1.28-4.28) |
8.47 (3.32-21.57) |
|
|||||||
|
pT |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| ≤25 mm |
1 |
0.004 |
1 |
0.00014 |
|
NS |
1 |
0.00096 |
|
NS |
|
NS |
1 |
0.00034 |
| >25 mm |
1.62 (1.17-2.24) |
2.16 (1.45-3.20) |
|
2.22 (1.38-3.55) |
|
|
1.97 (1.36-2.86) |
|||||||
|
ER |
|
|
|
- |
|
- |
|
|
|
|
|
|
|
|
|
Negative |
|
NS |
|
|
|
NS |
|
NS |
|
NS |
|
NS |
||
|
Positive |
|
|
|
|
|
|
|
|||||||
|
PR |
|
|
|
|
|
|
|
- |
|
- |
|
|
|
|
|
Negative |
|
NS |
|
NS |
|
NS |
|
|
|
NS |
|
NS |
||
|
Positive |
|
|
|
|
|
|
|
|||||||
|
ERBB2 |
|
|
|
|
|
|
|
|
|
|
|
- |
|
- |
|
Negative |
|
NS |
|
NS |
|
NS |
|
NS |
|
NS |
|
|
||
|
Positive |
|
|
|
|
|
|
|
|||||||
|
PIK3R1 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Underexpression |
1 |
0.0013 |
1 |
0.0076 |
|
NS |
1 |
0.043 |
|
NS |
1 |
0.018 |
1 |
0.024 |
|
Normal |
0.59 (0.43-0.81) |
0.62 (0.44-0.88) |
|
0.65 (0.43-0.99) |
|
0.40 (0.19-0.85) |
0.66 (0.46-0.95) |
|||||||
|
Overexpression |
0.35 (0.18-0.66) |
0.38 (0.19-0.77) |
|
0.42 (0.18-0.97) |
|
0.16 (0.03-0.73) |
0.44 (0.21-0.89) |
|||||||
|
PI3KCA |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Normal |
|
NS | |
NS | |
NS | |
NS | |
NS | 1 |
0.051 | |
NS |
| Mutated | 0.39 (0.15-1.00) | |||||||||||||
aHazard ratio (95% Confidential Interval). NS: not significant.
bMultivariate Cox analysis. NS: not significant.
The bold numbers stress important finding or overall characterisation of a group or p-value.