Figure 1.

17-AAG and NVP-AUY922 effects on cell proliferation. Pancreatic (A and C) and colorectal (B and D) carcinoma cell lines or primary cell cultures obtained from colorectal tumors excised to patients (E and F) were treated with DMSO or different concentrations of 17-AAG (A, B, and E) or NVP-AUY922 (C, D, and F) for 72 hours. Cells were stained with crystal violet, proliferation rates were determined by colorimetry, and the average of at least four experiments is represented and referred as percentage of control. Error bars are the SEM. Each experiment was performed in sextuplicate (n = 6).