Table 4.
Common ADR types observed
| Reaction type | All reactions | Reaction following GA b | ||
|---|---|---|---|---|
| |
N |
% of all reactions
a
|
N |
% of reaction types, where reaction followed GA |
| Nausea and/or vomiting |
400 |
27.5% |
295 |
73.8% |
| Pruritus |
243 |
16.7% |
232 |
95.5% |
| Constipation |
155 |
10.6% |
107 |
69.0% |
| Diarrhea (9/88 with vomiting) |
88 |
6.0% |
0 |
0.0% |
| Somnolence (without cardio-respiratory symptoms) |
50 |
3.4% |
34 |
68.0% |
| Respiratory depression (41)/arrest (3) |
44 |
3.0% |
43 |
97.7% |
| Candidiasis |
41 |
2.8% |
0 |
0.0% |
| Urinary retention |
40 |
2.7% |
37 |
92.5% |
| Rash |
31 |
2.1% |
3 |
9.7% |
| Hypokalemia |
25 |
1.7% |
0 |
0.0% |
| Hypotension |
22 |
1.5% |
9 |
40.9% |
| Hepatotoxicity(6)/increased transaminases (12)c |
18 |
1.2% |
1 |
5.6% |
| Stomatitis |
16 |
1.1% |
0 |
0.0% |
| Myoclonus |
15 |
1.0% |
14 |
93.3% |
| Pancytopenia |
13 |
<1% |
0 |
0.0% |
| Hyperglycemia |
12 |
<1% |
0 |
0.0% |
| Hypertension |
11 |
<1% |
2 |
18.2% |
| Allergic reactions |
10 |
<1% |
3 |
30.0% |
| Pain (4/10 pain in jaw, 2/10 back pain) |
10 |
<1% |
0 |
0.0% |
| Other reactions ( occurred <10 times) |
213 |
14.6% |
65 |
30.5% |
| Total | 1,457 | 845 | 58.0% | |
aIf the same patient experienced two types of reactions to the same medication(s) at the same time this would have been reported as one ADR case but will be listed here as two reaction types, for example, a patient with respiratory depression and bradycardia = one ADR case, but is listed as two reactions; breaction occurred post theater AND drugs given in theater and/or used in post-operative pain management were implicated; ctransaminases were raised in all cases. Additionally, if other parameters of liver function such as bilirubin and INR were also raised, we classified this as hepatotoxicity. ADR, adverse drug reaction, GA general anesthesia; N number, INR international normalized ratio.