Table 1.
Characteristics of the study population, categorized as pre– and post–lung transplantation
| Variable | Pretransplant (N = 14) | Post-Transplant (N = 42) | P Value |
|---|---|---|---|
| Age, yr | 60 (56–65) | 60 (57–64) | 0.86 |
| Male sex, no. (%) | 4 (29) | 20 (48) | 0.21 |
| Level of education, yr | 13.5 (12–16) | 13 (12–16) | 0.50 |
| Race or ethnic group, no. (%) | 0.70 | ||
| White non-Hispanic | 12 (86) | 33 (78) | |
| Black non-Hispanic | 0 (0) | 1 (2) | |
| Hispanic | 2 (14) | 4 (10) | |
| Other | 0 (0) | 4 (10) | |
| Pulmonary diagnosis, no. (%) | 0.18 | ||
| COPD | 6 (43) | 17 (40) | |
| Idiopathic pulmonary fibrosis | 3 (21) | 19 (45) | |
| Cystic fibrosis | 1 (7) | 2 (5) | |
| Other | 4 (29) | 4 (10) | |
| Coexisting conditions, no. (%) | |||
| Anxiety | 3 (21) | 12 (29) | 0.74 |
| Depression | 5 (36) | 17 (40) | 0.75 |
| Chronic kidney disease | 1 (7) | 17 (40) | 0.02 |
| Coronary artery disease | 4 (29) | 10 (24) | 0.73 |
| Congestive heart failure | 1 (7) | 1 (2) | 0.44 |
| Diabetes mellitus | 3 (21) | 28 (67) | 0.003 |
| Hypertension | 5 (36) | 22 (52) | 0.28 |
| Hyperlipidemia | 5 (36) | 20 (48) | 0.44 |
| Dementia | 0 (0) | 0 (0) | — |
| Cerebrovascular disease | 0 (0) | 0 (0) | — |
| Charlson Comorbidity Index score | 3 (3–4) | 5 (3–5) | 0.02 |
| Pulmonary hypertension | 0.19 | ||
| Normal | 9 (64) | 28 (67) | |
| Mild, mPAP 25–40 | 2 (14) | 12 (29) | |
| Moderate, mPAP 41–55 | 2 (14) | 1 (2) | |
| Severe, mPAP > 55 | 1 (7) | 1 (2) | |
| 6-min-walk test pretransplant, m | 964 (800–1,200) | 996 (865–996) | 0.97 |
| Operative (transplantation) variables | |||
| Transplant type, single, no. (%)* | 14 (33) | ||
| Cardiopulmonary bypass, no. (%) | 29 (69) | ||
| Cardiopulmonary bypass time, min | 249 (238–286) | ||
| Primary graft dysfunction, no. (%) | 10 (24) | ||
| Graft ischemia time, min | 243 (217–272) | ||
| Postoperative variables* | |||
| Physical function | |||
| Initial 6-min-walk test post-transplant, m | 879 (634–1,054) | ||
| Final 6-min-walk test post-transplant, m | 1,347 (1,247–1,525) | ||
| Distance gained, m† | 423 (324–528) | ||
Definition of abbreviations: COPD = chronic obstructive pulmonary disease; mPAP = mean pulmonary artery pressure.
Values expressed as a frequency (%) or median (interquartile range) unless otherwise specified.
*
One subject was status post repeat lung transplantation and one subject was status post heart-lung transplant.
†
Thirty-two subjects were tested after having completed physical therapy post-transplantation. Distance gained defined as final distance – initial distance (m).