Table 2.
Cognitive outcomes, mental health, resilience, and health-related quality of life
| Variable | Pretransplant (N = 14) | Post-Transplant (N = 42) | P Value |
|---|---|---|---|
| Cognition, MoCA score | 25 ± 2 | 24 ± 3 | 0.24 |
| Cognitive impairment, no. (%)* | 1.00 | ||
| None | 4 (29) | 12 (29) | |
| Mild | 10 (71) | 28 (67) | |
| Moderate or severe | 0 (0) | 2 (5) | |
| Anxiety score | 8 (5–17) | 7 (4–14) | 0.59 |
| Anxiety, no. (%) | 0.92 | ||
| Mild | 3 (21) | 9 (24) | |
| Moderate or severe | 4 (29) | 8 (21) | |
| Depression score | 40 (36–45) | 34 (29–40) | 0.05 |
| Depression, no. (%) | 0.62 | ||
| Mild | 1 (7) | 1 (3) | |
| Moderate or severe | 0 (0) | 1 (3) | |
| Posttraumatic stress score | 14 (13–17) | 16 (13–22) | 0.30 |
| Symptoms of PTSD, no. (%) | 1 (7) | 0 (0) | 0.27 |
| Resilience score† | 93 (82–93) | 87 (76–95) | 0.68 |
| Health-related quality of life, EuroQol | |||
| Descriptive score (5–15)‡ | 8 (7–8) | 6 (5–8) | 0.04 |
| Visual analog scale (0–100) | 52 (30–60) | 80 (60–90) | 0.001 |
Definition of abbreviations: MoCA = Montreal Cognitive Assessment; PTSD = posttraumatic stress disorder.
*
Mild cognitive impairment was defined as a score of 18–25 and moderate or severe impairment as <18. One point was added for patients with 12 or fewer years of education.
†
Resilience was assessed beginning in October 2012 (N = 30 subjects). Overall, 11 of 30 subjects (37%) were found to be highly resilient (score > 92) and 6 of 30 subjects (17%) had low (>1 SD below population mean scores) resilience.
‡
Greater score represents more perceived problems in dimensions assessed.